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Our client, a biopharmaceutical company based near Cambridge, is looking for a Scientist (T-Cell Engineering) to join their growing research team.
Candidates should be comfortable with a fast-paced, dynamic working environment and hold good communication skills to facilitate the necessary close interactions with the internal teams as well as external partners.
KEY RESPONSIBILITIES:
- Planning and execution of a wide range of robust experiments, technical studies, and tasks, working independently based on protocols and in line with departmental objectives.
- Assaying of our client’s engineered delivery vehicle using flow cytometry, western blot, ELISA, and immunofluorescence.
- Inform and implement the design of novel genetic constructs for use in T Cell engineering.
- Development of robust T Cell engineering platform.
- Development of T Cell functionality assays.
- Cell culture (propagation, banking, characterisation) of cell lines and primary cells.
- Timely, accurate recording and analysis of results and compliance with data integrity procedures.
- Timely presentation of data to the department and wider company.
- Contribution to critical interpretation of data to draw results driven hypotheses, with influence on project/function direction.
It is essential that candidates have the following skills and experience:
- A PhD with experience in T Cell biology (or equivalent experience gained in industry). Engineering of T Cells for the purpose of CAR-T generation with Lentiviral or CRISPR based systems is a plus.
- Experience handling and culturing a range of cell lines.
- Experience with CRISPR based editing of primary human T Cells, both KO and KI
- Experience with genetic approaches for quantifying T Cell engineering outcomes.
- Experience with assays of T Cell functionality and potency, especially in the context of CAR-T.
- Strong experience with flow cytometry-based assays.
- Experience with single cell sequencing assay.
- Fluency in spoken and written English.
- Proficiency with critical interpretation of data and implementation into an experimental cascade.
- Communication in a clear, well-structured, and professional manner with key stakeholders within the company on a regular basis.
- Contribution to authoring of technical and science reports which will feed into IND filings.
- Awareness of latest scientific literature in company-relevant projects and general scientific areas.
