Antibody Discovery and Engineering Scientist

Job Title: Antibody Discovery and Engineering Scientist - Global Biopharmaceutical

Contract: 12-month contract

Location: Slough

Salary: 28.53 PAYE/38.84 Umbrella

SRG are working with a Global Biopharmaceutical company to help them find a Antibody Discovery and Engineering Scientist to join their busy team.

This is an excellent opportunity to join a dynamic and thriving team of scientists helping to develop and validate new sequence-based and structure-based antibody design approaches. This includes elements of antibody hit identification, sequence optimisation and in silico de novo antibody design. This is a laboratory-based role where a detailed knowledge of molecular biology and microbiological methods, and a proven track record of antibody discovery or protein engineering would be a significant advantage.

Key Responsibilities will include:

• Play a key role in the discovery of therapeutic monoclonal antibodies to support the pipeline and help create value for patients suffering with serious disease.
• Using cutting-edge yeast display for the discovery and optimisation of human antibodies aligned with therapeutic targets.
• Design, construct, and perform selections using bespoke synthetic display libraries to support in silico de novo antibody discovery and optimisation projects.
• The preparation of next generation sequencing (NGS) libraries and their analyses to support antibody discovery and engineering of lead molecules.
• Working closely with computational and CADD scientists, co-develop and apply AI/Deep learning solutions and structure-based approaches to facilitate discovery and engineering of high-quality antibody molecules.
• Contribute to the development and implementation of new methodologies in antibody display and engineering.
• Work flexibly across project teams to ensure delivery of results against expected timelines.
• Present experimental data at cross-functional meetings

Candidate Requirements:

• A PhD (or equivalent) with molecular biology and protein biochemistry knowledge ideally within the antibody space.
• Knowledge and experience in the use of in vitro display libraries for either discovery, affinity maturation, or other protein engineering, preferably to include structure or deep sequence-guided insight would be desirable.
• Demonstrable experience of biochemical techniques for the characterisation of macromolecules such as flow-cytometry, surface plasmon resonance or Bio-layer interferometry would be beneficial.
• Skills in informatic and other computational platforms such as molecular visualisation and next generation sequencing data analysis would be advantageous.
• Highly motivated with excellent attention to detail and critical data analysis skills.
• A trusted ability to deliver to deadlines.
• Excellent communication skills.

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.