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Title: Senior Scientist- Large Molecule Discovery
Duration: 12+ months
Location: Stevenage, Hertfordshire SG1 2NY
Large Molecule Discovery within client is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation, to molecular engineering and biological and physiochemical profiling. Within the Large Molecule Discovery Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and develop ability profiling prior to candidate selection to continuously improve molecule quality and transform discovered leads into potential therapeutics.We are currently seeking an enthusiastic, dynamic and self-motivated scientist to join the Develop ability Technologies group within MDE and working within a matrix role. The role will be primarily lab focused, working with teams of scientists with diverse skills including protein biochemists, in vitro and ex vivo assay scientists, antibody pharmacologists and molecular biologists as well as in close partnership with other parts of the organisation. It will involve using high throughput methods to rapidly profile large panels of antibodies and performing interpretations on the generated data in the early discovery phase. These activities will focus on in vitro prediction of antibody characteristics during exposure in vivo.
Key responsibilities:o Running high throughput methods to predict in vitro antibody characteristics during exposure in vivo, which might include chromatography based analytical techniques (SEC-HPLC, CIEX-HPLC)as well as ELISA and flow based methods.o Design, qualify and execute experiments to characterise antibody panels e.g. non-specific binding measurements using flow cytometry and ELISA methods as well as determining binding of antibodies to antigen after incubation in serum.o Utilizing automated liquid handling systems to execute experimentso Planning, designing and executing experiments to enable key decisionso Working independently to analyse and interpret your data, providing clear recommendations to project teamso Effective recording and communication of your work in lab notebooks, lab reports and publishing/presenting both internally and externallyo Working effectively in matrix teams and delivering defined objectives in accordance with agreed timelineso Demonstrate exemplary scientific habits, actively keeping up to date with relevant literature and new technologieso Adhere to safety and other company rules and regulations, maintain lab equipment and reagentswhen appropriateo Developing & implementing high throughput methods to predict in vitro antibody characteristics during exposure in vivo
Why you?Qualifications & Skills:We are looking for professionals with these required skills to achieve our goals:• Graduate or post graduate degree in Biology, Biochemistry, Immunology or other relevant discipline;• A track record of recent scientific success through relevant post degree experience in academic orindustrial science;• Independence and competence performing relevant analytical/ biological research techniques ( inone or more of the following: immunoassay, flow cytometry, SEC- HPLC );• Demonstrated ability for experiment design and a variety of data analysis methods including anunderstanding of statistics;• Can demonstrate scientific knowledge of antibody structure and function;• Experience of the use and design of automated solutions to scientific workflows including liquidhandlers;• Ability to adapt quickly to new scientific areas & work across teams
Preferred Qualifications & Skills:If you have the following characteristics, it would be a plus:• An understanding of the antibody discovery process;• Proficient in automated data analysis and/or visualization software;• Good understanding of antibody clearance mechanisms and related concepts
