Back to searchSenior Scientist - Biopharmaceutical
Networker Global Limited
Posted 7 days ago, valid for 2 hours
Stevenage, Hertfordshire SG1 1PX
£22 - £24 per day
Full Time
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Sonic Summary
- The role of Senior Scientist - Biopharmaceuticals is a 12-month position located in Stevenage, offering a rate of £24.61 per hour on a PAYE basis.
- The position is focused on antibody engineering and developability profiling within the Biopharm Discovery Unit's Molecular Design and Engineering group.
- Candidates should ideally possess a graduate or postgraduate degree in Biology, Biochemistry, Immunology, or a related field, along with relevant post-degree experience.
- The role requires independence in performing analytical and biological research techniques, as well as a strong understanding of antibody structure and function.
- Successful applicants will be expected to demonstrate exemplary scientific habits and effectively communicate their findings while adhering to safety regulations.
Duration: 12 Months
Location: Stevenage
Rate: 24.61 p/h - PAYE
Role purpose / summary
Biopharm Discovery within is a department dedicated to the discovery of novel and effective biopharmaceutical medicines. This department comprises several complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering, biological and physiochemical profiling. Within the Biopharm Discovery Unit, the Molecular Design and Engineering (MDE) group takes accountability for antibody engineering and developability profiling prior to candidate selection to continuously improve molecule quality and transform discovered leads into potential therapeutics.
We are currently seeking an enthusiastic, dynamic and self-motivated scientist to join the Developability Technologies group within MDE, working within a matrix team. The role will be primarily lab focused, working with various scientists with diverse skill set (e.g. protein biochemists, in vitro and ex vivo assay scientists and antibody pharmacologists). It will involve using high throughput methods to rapidly profile large panels of antibodies and performing interpretations on the generated data in the early discovery phase. These activities will focus on in vitro prediction of antibody characteristics during exposure in vivo
Running high throughput methods to predict in vitro antibody characteristics during exposure in vivo, which might include chromatography based analytical techniques (SEC-HPLC, CIEX-HPLC) as well as ELISA and flow based methods.
Design, qualify and execute experiments to characterise antibody panels e.g. non-specific binding measurements using flow cytometry and ELISA methods as well as determining binding of antibodies to antigen after incubation in serum.
Utilizing automated liquid handling systems to execute experiments
Planning, designing and executing experiments to enable key decisions
Working independently to analyse and interpret your data, providing clear recommendations to project teams
Effective recording and communication of your work in lab notebooks, lab reports and publishing/presenting both internally and externally
Working effectively in matrix teams and delivering defined objectives in accordance with agreed timelines
Demonstrate exemplary scientific habits, actively keeping up to date with relevant literature and new technologies
Adhere to safety and other company rules and regulations, maintain lab equipment and reagents when appropriate
Developing & implementing high throughput methods to predict in vitro antibody characteristics during exposure in vivo
Key Skills/ requirements
To be successful in this role, youll ideally:
Graduate or post graduate degree in Biology, Biochemistry, Immunology or other relevant discipline;
A track record of recent scientific success through relevant post degree experience in academic or industrial science;
Independence and competence performing relevant analytical/ biological research techniques ( in one or more of the following: immunoassay, flow cytometry, SEC- HPLC );
Demonstrated ability for experiment design and a variety of data analysis methods including an understanding of statistics;
Can demonstrate scientific knowledge of antibody structure and function;
Experience of the use and design of automated solutions to scientific workflows including liquid handlers;
Ability to adapt quickly to new scientific areas & work across teams
Preferred Qualifications & Skills:
An understanding of the antibody discovery process;
Proficient in automated data analysis and/or visualization software;
Good understanding of antibody clearance mechanisms and related concepts
All profiles will be reviewed against the required skills and experience. Due to the high number of applications we will only be able to respond to successful applicants in the first instance. We thank you for your interest and the time taken to apply!
