Senior Scientist- Large Molecule

Senior Scientist - Global Pharmaceutical company

Contract: 12 months contract

Location: Stevenage, Hertfordshire

Salary: £26.76 PAYE, £34.03 Umbrella

Working pattern: onsite

SRG are working with a global pharmaceutical company to help them find a Senior scientist to join their busy team. This is an exciting opportunity for an enthusiastic scientist with relevant industrial experience.

We are currently seeking an enthusiastic, dynamic and self-motivated scientist to join the Developability Technologies group within MDE and working within a matrix role. The role will be primarily lab focused, working with teams of scientists with diverse skills including protein biochemists, in vitro and ex vivo assay scientists, antibody pharmacologists and molecular biologists. It will involve using high throughput methods to rapidly profile large panels of antibodies and performing interpretations on the generated data in the early discovery phase. These activities will focus on in vitro prediction of antibody characteristics during exposure in vivo.

Key Responsibilities will include:

• Running high throughput methods to predict in vitro antibody characteristics during exposure in vivo, which might include chromatography based analytical techniques (SEC-HPLC, CIEX-HPLC) as well as ELISA and flow based methods.
• Design, qualify and execute experiments to characterise antibody panels e.g. non-specific binding measurements using flow cytometry and ELISA methods as well as determining binding of antibodies to antigen after incubation in serum.
• Utilizing automated liquid handling systems to execute experiments
• Planning, designing and executing experiments to enable key decisions
• Working independently to analyse and interpret your data, providing clear recommendations to project teams
• Effective recording and communication of your work in lab notebooks, lab reports and publishing/presenting both internally and externally
• Working effectively in matrix teams and delivering defined objectives in accordance with agreed timelines
• Demonstrate exemplary scientific habits, actively keeping up to date with relevant literature and new technologies
• Adhere to safety and other company rules and regulations, maintain lab equipment and reagents when appropriate
• Developing & implementing high throughput methods to predict in vitro antibody characteristics during exposure in vivo

Candidate Requirements:

• Graduate or post graduate degree in Biology, Biochemistry, Immunology or other relevant discipline.
• A track record of recent scientific success through relevant post degree experience in academic or industrial science.
• Independence and competence performing relevant analytical/ biological research techniques ( in one or more of the following: immunoassay, flow cytometry, SEC- HPLC ).
• Demonstrated ability for experiment design and a variety of data analysis methods including an understanding of statistics.
• Can demonstrate scientific knowledge of antibody structure and function.
• Experience of the use and design of automated solutions to scientific workflows including liquid handlers.

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.