Senior Scientist Protein Chemistry

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Job Description

We are seeking a highly skilled and motivated PhD level Protein Chemist to report into Takeda’s Structural Biology organization. The ideal candidate will possess a strong background in the field of Protein Chemistry and/or Structural Biology and will use this expertise to produce and characterize proteins for structure determination by x-ray crystallography and cryo-EM as well as potential use in biochemical and biophysical assays to advance Takeda’s drug discovery programs.  A successful candidate will collaborate with external contract research organizations, internal protein production experts and multiple cross-functional project teams to plan and execute protein production requirements to progress Takeda’s pipeline.

The successful candidate will:      

• Plan and execute protein production campaigns for structural biology efforts of small molecule and/or biologic complexes with target proteins in collaboration with structural biologists and protein chemists utilizing in-house protein production capabilities and contract research organizations, including utilization of in-house equipment and database resources
• Analyze proprietary and public information to positively impact structure determination efforts, reagent or antigen protein production and characterization and/or antibody design, optimization and characterization
• Work collaboratively and communicate clearly with interdisciplinary teams, including structural biologists, protein chemists, in vitro pharmacologists, medicinal and computational chemists, project management to advance pipeline projects
• Clearly communicate protein production and characterization plans, priorities, results and timelines to diverse audiences including structural biology group, project teams, department colleagues and senior leadership

Desired qualifications include:

• PhD degree in a scientific discipline (Structural Biology, Biophysics, Biochemistry/Enzymology, Protein Chemistry) with 5+ years of protein production responsibilities in industry setting; MS or BS candidates with suitable experience also considered
• Demonstrated track record of successful hands-on high-quality protein production (construct design, cloning, expression, purification, optimization, characterization) of protein reagents, antigens and/or antibodies or other biologics therapeutics for drug discovery teams  
• Experience in protein production utilizing contract research organizations required, including efficient management of external resources, successful troubleshooting of challenging proteins, clear written and verbal communication and detailed documentation
• Success in design, expression and purification of membrane proteins and/or multi-protein complexes as well as extensive knowledge of and/or experience in structural biology methodologies, biochemical and/or biophysical assays highly desirable
• Passion for learning and advancing protein production capabilities and drug discovery pipelines, including proactive investigation of new techniques and capabilities, advanced software / hardware and innovative experimental approaches
• Ability to work collaboratively in a fast-paced, matrixed environment with a collaborative and proactive mindset, motivated by a desire to create therapeutic molecules for the benefit of patients in need worldwide

Takeda Compensation and Benefits Summary

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EEO Statement

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Job Exempt